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Diabetes mellitus and deafness (DAD) or maternally inherited diabetes and deafness (MIDD) is a subtype of diabetes which is caused from a point mutation at position 3243 in human mitochondrial DNA, which consists of a circular genome. This affects the gene encoding tRNALeu.〔Murphy R, Turnbull DM, Walker M, Hattersley AT "Clinical features, diagnosis and management of maternally inherited diabetes and deafness (MIDD) associated with the 3243A>G mitochondrial point mutation. " Diabet. Med. 2008 , 25(4) , 383-99. 〕〔de Andrade PB, Rubi B, Frigerio F, van den Ouweland JM, Maassen JA, Maechler P. "Diabetes-associated mitochondrial DNA mutation A3243G impairs cellular metabolic pathways necessary for beta cell function" ''Diabetologia''. 2006 Aug;49(8):1816-26.〕 Because mitochondrial DNA is only found in oocytes and is not present in spermatozoa, this disease is inherited from maternal family members only.〔 As indicated by the name, MIDD is characterized by diabetes and sensorineural hearing loss.〔 ==Alternative names== *diabetes and deafness, maternally inherited; MIDD *Ballinger-Wallace syndrome *diabetes mellitus, type II, with deafness *noninsulin-dependent diabetes mellitus with deafness *NIDDM with deafness 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Diabetes mellitus and deafness」の詳細全文を読む スポンサード リンク
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